NAD+ Delivery Methods Compared: Injectable vs. Nasal Spray

Understanding NAD+ Supplementation

NAD+ supplementation has gained significant attention in the longevity and functional medicine communities. However, not all NAD+ delivery methods are created equal. The way you take NAD+ dramatically affects how much actually reaches your bloodstream and cells—a concept called bioavailability.

This article compares the two most effective NAD+ delivery methods: subcutaneous injection and nasal spray. Understanding the differences helps you choose the option that best fits your goals, lifestyle, and preferences.

NAD+ Bioavailability: Why Delivery Matters

Oral NAD+ supplements face a significant challenge—they must survive the digestive system where enzymes rapidly break down NAD+. Most oral NAD+ is degraded before it can be absorbed, resulting in poor bioavailability. This is why alternative delivery methods have become preferred.

Injectable and nasal delivery both bypass the digestive system, preserving NAD+ integrity. These routes allow NAD+ to enter circulation quickly and efficiently, producing more noticeable effects than oral supplements.

The First-Pass Metabolism Problem

When you take something orally, it passes through your liver before entering general circulation—this is called first-pass metabolism. The liver contains enzymes that break down many compounds, including NAD+. Injectable and nasal routes avoid this issue entirely, delivering NAD+ directly where it's needed.

NAD+ Injectable: Maximum Bioavailability

Injectable NAD+ ($299/month) delivers the compound directly into subcutaneous tissue where it's rapidly absorbed into circulation. This method provides the highest bioavailability of any NAD+ supplementation approach. For those seeking maximum effects, injection is the gold standard.

The injection process involves a small needle inserting NAD+ just beneath the skin, typically in the abdomen or thigh. Most users find the process simple and relatively painless after the first few attempts. Injections are typically performed 2-3 times per week.

Benefits of Injectable NAD+

• Highest bioavailability of any delivery method
• Most potent effects on energy and cellular function
• Precise dosing with each injection
• Well-suited for therapeutic loading protocols

NAD+ Nasal Spray: Convenience and Consistency

NAD+ Nasal Spray ($199/month) offers an excellent balance of effectiveness and convenience. The nasal mucosa provides good absorption, bypassing the digestive system while eliminating the need for injections. Many users prefer this method for daily maintenance.

Nasal administration is quick and easy—simply spray into each nostril as directed. This method works well for those who prefer to avoid injections or need a travel-friendly option. The lower price point also makes it more accessible for long-term use.

Benefits of Nasal Spray NAD+

• No injections required
• Easy to use anywhere, anytime
• Lower cost for long-term maintenance
• Good bioavailability through nasal mucosa

Which Method Is Right for You?

Many patients use both methods strategically. Injectable NAD+ provides powerful initial effects and periodic boosting. Nasal spray offers convenient daily maintenance between injection sessions. Your optimal approach depends on your goals, budget, and preferences.

For those new to NAD+ therapy, starting with injectable can provide more noticeable initial benefits. Once you've experienced the effects, transitioning to nasal spray for maintenance is a cost-effective strategy. Our team can help you develop a personalized NAD+ protocol.